PhD Student
My PhD investigates the role of glial lipid homeostasis in Alzheimer’s disease, with a particular focus on the LSR (Lipolysis Stimulated Lipoprotein Receptor) and its involvement in ApoE regulation.
I am specifically interested in the crosstalk between astrocytes and microglia, whose disruption contributes to neurodegenerative processes. My work relies on cell lines and primary glial cultures, as well as a CRISPR-Cas9 knockout model for the LSR receptor, and aims to:
Characterize the molecular mechanisms by which LSR regulates glial lipid homeostasis and modulates the neuroinflammatory response;
Identify and screen molecules capable of modulating the LSR/ApoE pathway from a therapeutic perspective.
3rd-year PhD student at the NGERE unit (Inserm), working on the modulation of glial response in Alzheimer’s disease via ApoE regulation, with a focus on astrocyte/microglia crosstalk and the role of the LSR receptor in glial lipid homeostasis.
Teaching: DCCE, 48h/year.
Collective responsibilities: member of the BioSE Doctoral School board; former president of the AD’UL Team association.
Third-year PhD candidate (NGERE Unit, Inserm), specialized in neuro-immunology and cell biology. Master’s in Biotechnology (2nd/18). Experience in university teaching (DCCE), scientific communication, and collective engagement within the doctoral school.
Experience
PhD – NGERE, Université de Lorraine (2024-2027)
Gliosis Modulation in Alzheimer’s Disease through ApoE Regulation
Investigating astrocyte/microglia crosstalk and the role of the LSR receptor in glial lipid homeostasis (CRISPR-Cas9 knockout model, cell lines, primary cultures). DCCE teaching contract (48h/year). Member of the BioSE Doctoral School Council. Former president of the AD’UL Team association.
Master’s Research Internship – NGERE Inserm U1256 (2024)
Cholesterol trafficking between neurons and glia and inflammation in Alzheimer’s disease
Master’s 1 / Bachelor’s Internships – Inserm U1114, CPN Laxou (2023)
Visual electrophysiological measurements (flash-EEG) in early-phase psychosis
Education
Master’s in Biotechnology, Applied Neurophysiology – Nancy (2023-2024)
Master’s 1 in Biotechnology, Cell Biology and Physiology – Nancy (2022-2023)
Bachelor’s in Cell Biology and Animal Physiology – Nancy (2019-2022)
Communications
13th Alzheimer’s Foundation Meetings, Paris (2025); BioSE Scientific Days (2025-2026); IHU Congress (2025) — Posters and Flash posters
Technical Skills
Cell culture, CRISPR-Cas9, flow cytometry, RT-qPCR, immunofluorescence, immunopanning, Western Blot, ELISA, confocal microscopy, animal experimentation (Level “Concepteur” certification)
Software: Prism-GraphPad, BioRad-CFX Maestro, iBright, Incucyte, MatLab
Languages: French (native), English (fluent)
