Professor - Teacher / Researcher
My research focuses on deciphering the neuron-glial dialogue in pathophysiological processes (aging, trauma) and identifying neuroprotective strategies. In the context of pathological aging, together with Dr. Kaminki, we are particularly interested in the link between neuroinflammatory processes and the disruption of lipid (cholesterol) trafficking in Alzheimer’s disease, as well as in identifying mechanisms to limit the deleterious effects of these neurodegenerative processes. In the context of traumatic central nervous system injuries (optic nerve), we are working with Dr. Castell to develop 3D implants made from bio-based materials to enable directed axonal regrowth and nerve regeneration. These various research projects are conducted in partnership with laboratories in Nancy (DCAC, IMOPA, IJL), throughout France (PBS, Evreux), and internationally (Tufts University, University of Leipzig).
Full professor of Neuroscience and Physiology at the Faculty of Science and Technology in Nancy; Member of the Research Ethic Committee of the University of Lorraine (CerUL)
After completing a doctoral dissertation funded by the Alsace Region in 1999, I conducted two postdoctoral fellowships: the first in Boston as part of Dr. Brunken’s team at Harvard and then at Tufts (2000–2002), focusing on laminins in the retina; and the second as part of Dr. Pfrieger’s team at the INCI in Strasbourg (2002–2008) on the regulation of glial-derived cholesterol. I then shifted my focus to biomaterials in neuroscience and secured a tenured-track faculty position (Juniorprofessor W1) at the University of Leipzig in the research laboratory of the Department of Ophthalmology led by Prof. Wiedemann, where I headed a research team (2009–2013) on innovative approaches in neuro-ophthalmology. After defending my HDR at the University of Technology of Compiègne in December 2012, I was appointed full professor at the University of Lorraine in 2013. Within the NGERE laboratory, I am conducting research on neuron-glial interactions in neurodegenerative processes and the modulation of neuroinflammation in pathological aging (Alzheimer’s disease) and central nervous system trauma (optic nerve lesions).
