🔬This year, the laboratory is delighted to be contributing to two new projects funded by the ANR (French National Research Agency): ERNEST and PARKREDOX!
These two collaborative projects illustrate the diversity and complementarity of the research carried out at the laboratory into brain ageing and neurodegenerative diseases. đź§
🔹 ANR ERNEST – New Hybrid Nanoliposome as a Delivery System for Ageing Brain Function
Coordinated by Elmira Arab-Tehrany (LIBio), the ERNEST project has been awarded €550,000 in funding over 42 months and brings together seven research teams!
🎯Its aim? To develop a new nutritional strategy to prevent brain ageing and age-related cognitive decline, using hybrid nanoliposomes rich in polyunsaturated fatty acids (PUFAs), derived from fish by-products and capable of transporting curcumin to the brain and harnessing its complementary effects on the mechanisms associated with brain ageing.
🧪Within the laboratory, Catherine Malaplate, the NGERE Work Package lead, along with Thierry Oster and Fathia Djelti, project investigators, will contribute in particular to studying the effects of these nanovectors on neurons and neuronal membranes, their neuroprotective potential and their in vivo validation, working in close collaboration with the complementary expertise of the various consortium partners.
🔹 ANR PARKREDOX – Redox homeostasis of a multifunctional protein playing a key role in Parkinson’s disease
Coordinated by Sophie Rahuel-Clermont (IMoPA), with Carine Bossenmeyer-Pourie representing NGERE and @Audrey Beaussart representing the CBMN – Based at the Institute of Chemistry & Biology of Membranes and Nano-objects in Bordeaux, PARKREDOX is a 48-month collaborative project focusing on the role of the DJ-1/Park7 protein in the pathophysiology of Parkinson’s disease.
🎯Its aim? To understand how the redox status of DJ-1 influences its functions and the protein aggregation mechanisms associated with the disease.
🔬To achieve this, three complementary approaches will be used: redox enzymology, biophysics – notably native mass spectrometry and atomic force microscopy (AFM) – and in vivo studies, using proteomics and cellular imaging on cells derived from a cohort of patients with Parkinson’s disease.
👏 Congratulations to all the teams involved in securing these two grants! 🎉
These two successes further strengthen NGERE’s collaborations and support the development of innovative research to better #understand, #prevent and #address the mechanisms of brain ageing and neurodegenerative diseases.
